Hista-Digest

Hista-Digest

Hista-Digest

  • Supplement Facts for Hista-Digest
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Hista-Digest

Hista-Digest

Hista-Digest is a premium DAO supplement designed to support healthy histamine metabolism. Diamine oxidase (DAO) is the key enzyme your body uses to break down histamine in foods—yet many people don’t make enough of it on their own. By providing direct DAO support, Hista-Digest helps ease histamine-related discomforts so you can enjoy meals with greater confidence.

  • Take Hista-Digest if you want support with:
  • Occasional digestive upset after high-histamine foods
  • Calming flushing and skin reactivity
  • Relieving sinus pressure and nasal congestion
  • Promoting greater comfort and flexibility in your diet
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Clinician Formulated

Clinician Formulated

Gluten-Free

Gluten-Free

Dairy-Free

Dairy-Free

Soy-Free

Soy-Free

Tree Nut-Free

Tree Nut-Free

Shellfish-Free

Shellfish-Free

Egg-Free

Egg-Free

Key Benefits

Supports Histamine Breakdown

Targeted DAO enzyme activity helps metabolize histamine from food.

Eases Histamine-Related Symptoms

Helps reduce occasional flushing, digestive discomfort, or sinus irritation linked to histamine sensitivity.

Fast-Acting Gut Support

Works in the digestive tract where histamine breakdown is needed most—before it enters circulation.

Clean, Research-Inspired Formula

Made with pure, high-quality DAO enzyme and without common irritants or fillers.

Why Choose
Hista-Digest?

1
Confidence at Mealtimes
Eat a wider variety of foods without worrying as much about histamine-triggered reactions.
2
Science-Backed Enzyme Activity
Provides clinically relevant DAO activity right where you need it most: in your digestive tract.
3
Rapid Relief Support
Designed to work quickly in the gut to break down histamine before it enters circulation.
4
Trusted, Research-Inspired Formulation
Developed with clinical insight for people seeking a reliable DAO supplement.
5
Gut-Smart Formulation
Uses only what’s necessary for stability and effectiveness—no unnecessary additives.

What the Research Shows

Diamine oxidase (DAO) is the main enzyme responsible for breaking down histamine from food before it enters the bloodstream. When DAO activity is low, histamine can build up and trigger uncomfortable symptoms in sensitive individuals. Supplementing with DAO has been studied as a way to support histamine balance and improve quality of life.

  • DAO levels are lower in people with histamine intolerance. Multiple studies show that patients with histamine intolerance consistently have reduced DAO enzyme activity compared to healthy controls. [1]
  • Supplemental DAO can reduce histamine-related symptoms. In clinical trials, DAO supplementation has been shown to decrease common histamine-related issues such as digestive upset, headaches, skin flushing, and nasal congestion. [2]
  • DAO may improve meal tolerance and overall wellbeing. A 2020 open-label study found that people taking DAO reported significant improvements in food-related quality-of-life scores, especially in the digestive and skin symptom categories. [3]

Why Dr. Ruscio Recommends It

Why Dr. Ruscio Recommends It

Breaks Down Histamine at the Source

DAO directly breaks down histamine in the gut, where reactions often begin. By supplying the enzyme your body may not make enough of, Hista-Digest helps reduce histamine burden at the source.

Science Backs DAO’s Benefits

DAO supplementation has been studied for its role in improving food-related tolerance and reducing histamine-driven discomfort. While more research is always welcome, existing studies consistently point toward benefits for digestive, skin, and sinus health.

Best for Food-Triggered Symptoms

In my clinic, DAO support is most helpful for patients who:

  • Experience histamine-related reactions such as flushing, sinus irritation, or post-meal digestive upset.
  • Notice symptoms worsen after high-histamine foods (e.g., wine, aged cheese, fermented foods).
  • Are working through histamine intolerance as part of a broader gut-healing program.
Comfort While You Heal

I often see patients improve when DAO is introduced as a bridge supplement—helping them tolerate a wider range of foods while we address underlying gut health. A DAO supplement but can significantly ease symptoms and improve quality of life during recovery.