PureLut®

PureLut®

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PureLut®

PureLut®

PureLut® delivers pure luteolin, a plant flavonoid that supports healthy mast cell activity, in an olive oil softgel designed for better absorption and gentler tolerance.*

  • Supports healthy mast cell activity and a balanced histamine response.*

  • Supports a healthy inflammatory response in the gut and the brain.*

  • Delivers single-ingredient luteolin, a simpler option for people who react to multi-flavonoid formulas.*

  • Uses an olive oil base to support flavonoid absorption.*

  • Third-party tested by Eurofins for purity and label accuracy.

Gluten-Free

Gluten-Free

Shellfish-Free

Shellfish-Free

Soy-Free

Soy-Free

Casein-Free

Casein-Free

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Key Benefits

Calms Overactive Mast Cells

Supports healthy mast cell activity, which helps keep histamine release in a normal range.*

Supports Brain and Gut Comfort

Supports a healthy inflammatory response in the tissues where mast cells are most active.*

Gentle on Sensitive Systems

Single-ingredient luteolin, without the extra flavonoids that can bother phenol-sensitive people.

Built for Absorption

An olive oil softgel helps your body take in a compound that is otherwise poorly absorbed.*

Why Choose
PureLut®?

1
Made for Sensitive People
Many mast cell formulas combine luteolin with quercetin, rutin, and other flavonoids. PureLut® keeps it to luteolin alone, which makes it easier to tell what is helping and what isn't.
2
Clean Sourcing
The luteolin comes from citrus and Sophora japonica rather than peanut shells, a common source that can be a concern for people with plant or peanut sensitivities.
3
Simple to Start, Easy to Build On
A small daily softgel makes PureLut® an easy first step for mast cell support. If you want broader histamine support later, it pairs well with quercetin.

How to Use It

How to Use It

  • Take 1 softgel daily, per label, or as directed by a healthcare professional.

Why Dr. Ruscio Recommends It

Why Dr. Ruscio Recommends It


Targets a Common Driver of Histamine Symptoms

In cultured human mast cell research, luteolin reduced the release of histamine and other inflammatory compounds, outperforming cromolyn, a prescription mast cell stabilizer, in the same lab setting [1, 2].*


A Better Fit for Reactive Patients

Some people with histamine issues react to flavonoid supplements themselves. A single-ingredient formula lets them start low and build tolerance with fewer variables.


Works Where Many Flavonoids Can't

Luteolin appears able to cross the blood-brain barrier, which is why it is being studied for brain fog and neuroinflammation [3].*


One Piece of the Plan

Histamine and mast cell symptoms often overlap with gut issues like SIBO or dysbiosis. We use luteolin to support symptom resilience while the underlying gut picture is addressed.

Frequently Asked Questions

Frequently Asked Questions


What is luteolin?

Luteolin is a plant compound found in foods like celery, parsley, thyme, peppers, and chamomile. It belongs to the flavonoid family, which is known for antioxidant and anti-inflammatory effects. Getting the amounts used in research from food alone is difficult, which is why many people use a supplement.


How is luteolin different from quercetin?

Both are flavonoids that support healthy mast cell activity. Quercetin has more research behind it for seasonal allergies. Luteolin is often preferred when brain fog or nervous-system symptoms are part of the picture, since it appears to reach the brain more readily [3]. Many people take both.


Is luteolin safe?

Available research suggests luteolin is generally well tolerated, though long-term human data is limited. Possible side effects include stomach upset, nausea, headache, or fatigue, which seem more common at higher doses.