The Biota Clear series provides powerful, botanical support for gut and immune function via multiple mechanisms:
- Helps to restore healthy balance to the gut ecosystem
- Exerts powerful anti-bacterial, anti-fungal, anti-parasitic, and anti-biofilm activity
- Provides a milder alternative to prescription antibiotics and antifungals for stubborn gut dysbiosis
- Produces anti-inflammatory benefits and may have antidepressant effects
- May promote healthy motility
- May reduce pain
- Long history of use by traditional cultures to treat digestive conditions.
- Helps correct stubborn microbial imbalances in the gut
- Fights bad bugs
- May promote healthy motility and reduce inflammation
- Dr. Ruscio’s custom formulation
- Based upon published research & Dr. Ruscio’s clinical experience
- For correcting microbial imbalances in the gut
Take 3 capsules twice daily together with Biota Clear 1b
Rotate with Biota Clear 2a + 2b after one month
For ongoing health maintenance, take 2 capsules daily
Can be taken with or without food
- Contains carvacrol and thymol, the principal active compounds in oil of oregano.
- Formulated from the highest quality oil of oregano extract.
- Free of: wheat, gluten, soy, milk/casein, eggs, fish, shellfish, tree nuts and peanuts.
- Contains no artificial colors, flavors, or preservatives.
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You CAN Overcome Brain Fog & Depression by Healing Your Gut - Harman Shares Her Story. Ultimately she was free of all her symptoms in only 3-4 months. https://drruscio.com/overcome-...
Why Dr. Ruscio Recommends it
- In some cases imbalances of the gut microbiota persist despite healthy inputs (better sleep, reduced stress, exercise, time in nature, diet and probiotics). This is where a gentle nudge with herbal antimicrobials can help recalibrate the gut ecosystem to a healthier equilibrium.
The best research data we have for antimicrobials is for the non-herbal antibiotic rifaximin (aka Xifaxan) which has clearly been shown to reduce unwanted bacteria in SIBO [1, 2] and is FDA approved for treating IBS [3, 4].
However, return of symptoms after treatment is somewhat common after rifaximin. Why? I believe this tends to happen when long-term supports are not in place. So, when the crutch of the antibiotic is gone, the gut ecosystem slowly returns to its imbalanced state.
Herbal antimicrobials have more beneficial side benefits when compared with rifaximin. They are anti-inflammatory and perhaps even antidepressant [7, 8]. Many plant-based antimicrobials act against bacteria, fungi, and protozoa while prescription antibiotics mostly work against bacteria .
Our Biota-Clear line of antimicrobials has been shaped by my clinical experience and the published literature.
An overwhelming amount of anecdotal data from patients and from readers suggests this approach works well, even for those who have somewhat chronic and severe conditions.
What the Research Shows
- Herbal preparations may be as effective as prescription antibiotics at treating SIBO and IBS [5, 6].
- Rotating antimicrobial treatments may be 20% more effective than a single treatment for remediating SIBO 
Six weeks of 600 mg of daily oregano oil (O. vulgare) eliminated parasites in 13 individuals and improved GI symptoms in seven of the 11 patients with Blastocystis hominis .
Thymol and carvacrol improved symptoms in IBS patients relative to placebo .
Oregano extracts demonstrated antimicrobial, antiviral, antioxidant, insecticidal, anticancer, hepatoprotective, genotoxic, antidiabetic, cholinesterase inhibitory, anti-inflammatory, and analgesic actions .
A study of Iranian Traditional Medicine resources found that oregano was among the foods and spices that could be considered as medicinal foods for depressed patients . Animal studies also suggest that oregano extracts have a potential mood-enhancing effect .
reduces gut inflammation,
stimulates digestive enzymes,
works as an ileal antispasmodic and anti-spasmolytic,
inhibits gastric mucosal injury, and
influences gastric maturation and function in animal studies .
Oregano powder increased villi height (an important marker of the health of the gut lining) in poultry. It hardly affected overall microbial diversity, but reduced known pathogens, like Proteus, Klebsiella, and Staphylococcus .
- An in vitro (petri dish) study found that oregano infusion and oregano essential oil demonstrated antibacterial activity against 23 different bacterial species, with maximal activity against Bacillus laterosporus, Staph saprophyticus, B. polymyxa, and B. circulans .
I've worked with some of the best minds in gut health and of all I've tried Dr. Ruscio's antimicrobials were one of the most impactful interventions for my gut.
New York Times best selling author
How to Use it
As part of Dr. Rusico’s protocol
Refer to the full Great-in-8 protocol that Dr. Ruscio uses in his clinic and outlines in his book, Healthy Gut, Healthy You.
In a low dose for ongoing maintenance
After going through the full protocol, a lower dose can be used for a few additional months to help encourage a healthy rebalancing in the gut.
For periodic relapses
Life happens as do relapses. If so, a revisitation of the full protocol can help get you back on track. Make sure to only do this after first revisiting diet and probiotics.
- 120 Soft Gels
Frequently Asked Questions
Can I Start My Gut Healing Program With Antimicrobials?
Yes, but before taking herbal antimicrobials, it’s important to first set the foundation for gut health by getting adequate sleep, reducing stress, exercising, spending time in nature, improving diet and taking high-quality probiotic supplements. That’s why antimicrobials are Step 3 of my Great-in-8 gut healing protocol. These foundational approaches set the stage for antimicrobial treatment and support long-term success once antimicrobial treatment is completed.
What’s the Suggested Duration of an Antimicrobial Treatment?
The Great-in-8 protocol recommends beginning with a 2-month course of treatment, rotating between Biota Clear 1a/1b and Biota Clear 2a/2b. An assessment at the end of the 2-month treatment will help you determine if additional treatments are needed.
Are Die-Off Reactions Possible?
Die-off reactions are an uncommon side effect that can occur when bad microbes die inside your body as a result of taking antimicrobials. Die-off may lead to:
Symptoms are usually temporary and are generally a sign that antimicrobial supplements are working. If symptoms last longer than a week, you may be intolerant of the herbal formula.
What Can I Do to Reduce Die-Off Reactions?
Reduce your dosage until you no longer experience reactions and then gradually increase to reach full dosage. If you continue to have symptoms, it’s best to switch to another herbal antimicrobial product.
Why Do You Sell Several Different Biota-Clear Products?
Research suggests that rotating antimicrobial treatments is 20% more effective than single treatments for remediating SIBO . Rotating antimicrobials can also help to prevent antimicrobial resistance, which is when microorganisms adapt and become less susceptible antimicrobial agents.