Biota-Clear 1b

Biota-Clear 1b

Biota-Clear 1b

Pairs with Biota-Clear 1a Step 3 of the Great-in-8 Protocol
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Biota-Clear 1b

Biota-Clear 1b

Pairs with Biota-Clear 1a Step 3 of the Great-in-8 Protocol

The Biota Clear series provides powerful, botanical support for gut and immune function via multiple mechanisms:

  • Helps to restore healthy balance to the gut ecosystem*

  • Exerts powerful anti-bacterial, anti-fungal, anti-parasitic, and anti-biofilm activity*

  • Provides a milder alternative to prescription antibiotics and antifungals for stubborn gut dysbiosis*

  • Produces anti-inflammatory benefits and may have antidepressant effects*

  • May promote healthy motility* 

  • May reduce pain*

  • Long history of use by traditional cultures to treat digestive conditions*.

Wheat-Free

Wheat-Free

Gluten-Free

Gluten-Free

Soy-Free

Soy-Free

Casein-Free

Casein-Free

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How to UseBiota-Clear 1b

On Its Own

For general microbial support, outside a structured protocol.

Dose
1–2 capsules, twice daily

As Part of the Biota-Clear Protocol

Used with Biota-Clear 1a as the antimicrobial phase, often rotated with the 2a/2b formulas.
Dose
2 capsules twice daily, alongside 1a
Pairs with: Biota-Clear 1a

As Part of the Biofilm Protocol

Weeks 1–4
2 capsules twice daily, alongside Biota-Clear 1a (4 caps 2×) and Biota-Dissolve (3 caps 2×, away from meals)
Weeks 5–8
Rotates to Biota-Clear 2a + 2b
Full protocol and dosing chart

*Typically used alongside Biota-Clear 1a and rotated with other Biota-Clear formulas over time.

Why does the label say “Step 3”?

Biota-Clear’s label reflects Biota-Clear 1b’s place in the Great-in-8 protocol from Dr. Ruscio’s book, Healthy Gut, Healthy You. Steps 1 and 2 are foundational work (diet and lifestyle, then probiotics) that typically come before antimicrobials. Biota-Clear 1a and 1b are the antimicrobial step, used together.

Explore the protocol
Great-in-8 · first three steps
Step 1: Diet & lifestyle Foundational work
Step 2: Probiotics Support before antimicrobials
Step 3: Antimicrobials Biota-Clear 1a + 1b, used together

Why Choose
Biota-Clear 1b?

1
Potent Herbal Ingredients
Features a blend wormwood, black walnut, and other botanicals known for their gut-supportive properties.
2
Research-Driven Formula
Crafted based on published research and Dr. Ruscio's clinical insights for targeted, effective relief.
3
Purity and Safety
Prioritizes your health with a formula free from common allergens and artificial additives, ensuring a natural approach to gut health.

Breaking Through SIBO Biofilms

  • Biofilms may allow certain microbes to persist and limit treatment progress. In this video, I explain how our clinical team uses the Biota-Clear formulas in a rotating protocol designed to help disrupt biofilms and support healthier microbial balance.

  • Want to see how the full protocol works?

  • Explore the Biota-Clear Protocol →

What the Research Shows

  • Herbal preparations may be as effective as prescription antibiotics at treating SIBO and IBS [6].
  • Rotating antimicrobial treatments may be 20% more effective than a single treatment for remediating SIBO [10].
  • Berberine
  • A randomized clinical trial (gold standard research) found that 8 weeks of berberine reduced the frequency of diarrhea, abdominal pain, and urgency, and improved quality of life in IBS-D patients [5]. 
  • Animal study data indicates that berberine sets in train changes that may lead to reduced intestinal lining inflammation. Berberine also lowered gut sensitivity [11].
  • A systematic review / meta-analysis (SR/MA) of 13 randomized controlled trials (RCTs) found that adding berberine to standard therapy for H. pylori improved the eradication rate, raised the peptic ulcer healing rate, and reduced clinical symptoms and side effects (compared to standard therapy without berberine) [12].
  • A 2019 SR/MA of 5 RCTs found that berberine likely decreased serum CRP  (c-reactive protein) levels, thus relieving chronic inflammation [13].
  • Berberine reduced blood glucose, HbA1c, triglycerides, total cholesterol, and LDL-C compared with placebo [14].
  • A 2015 rat study found berberine improved IBS-D symptoms, possibly via opioid receptors [15].
  • Artemisinin (Artemisia annua, Sweet Wormwood) 
  • Artemisinin has been found in animal, in vitro, and some human clinical studies, to exhibit antimicrobial, anti-inflammatory, and gut microbiome modulating effects. For example:
  • Artemisinin helped in the treatment of malaria, resolving symptoms and  inhibiting malarial parasites (though with limited efficacy where parasites had developed resistance) [16, 17, 18, 19].
  • A 2020 study found that mice treated with dihydroartemisinin (DHA), a semisynthetic form of artemisinin, had, higher bacterial diversity (including increased Firmicutes and Saccharibacteria and decreased Deferribacteres and Actinobacteria relative to controls) [20].
  • In vitro studies show that artemisinin demonstrates anti-fungal and anti-yeast activity [21, 22].
  • Caprylic Acid 
  • Caprylic acid can reduce the bad bacteria animals and chickens carry in their guts according to a number of studies [23, 24, 25].
  • Neurodegenerative disease models suggest that caprylic acid may confer neuroprotective and mitochondria-protective effects and may strengthen antitumor actions in the case of brain cancer [26].
  • Black Walnut
  • An in vitro study found that black walnut tannins demonstrated antibacterial effects against Listeria, S. aureus, E. coli, Brochothrix thermosphacta, Pseudomonas fragi, Salmonella, and Lactobacillus plantarum [27].

Overall rating: 4.3835616 / 5 from 73 reviews.

AI Generated Review Summary

Summary topics

Review topics: ["smell","improvement","skin","difference","results","feeling","effects","capsules","symptoms","dose","stomach","supplement","pain","treatment","inflammation","bloating"].

Review highlights

Reviews

Biota clear 1b

"This product has helped me with bloating and gastic pain. . . . I am happy to have stared this product. . . . I cry everyday to have relief . . I feel I might overcome IBS or have more control of the systoms And extreme pain. . . . Thank you . . . ."

— Julie l. (5/5)

Disappointed

"The Biota Clear system is confusing—the website was confusing to find the information of what to use and when. When I finally found the information, it wasn’t clear—there is way too much going on on the webpage and you have to scroll down to get a somewhat clear idea of the steps. I appreciated the study and the YouTube video about the study; those were helpful. I finally determined that this system is what I needed based on my symptoms. But once I got it, I realized the label says “Step 3”. What are steps 1 & 2? If there are steps 1&2, why isn’t that stated anywhere on the page with a link to steps 1&2? I decided to use it anyway based on the product and symptoms description— starting with the Biota Dissolve, the 1a & 1b as directed. After 3 days everything got worse and unbearable. I had to stop taking the meds, as it was affecting everything from sleep, to being at work, my daily activities, etc. I couldn’t function. I got terrible watery stool immediately after eating, and intense inflammation. I’m disappointed as I had high hopes, and it’s not a cheap product line. But at least I know now. I even tried the Elemental Heal I have to see if maybe I just needed to consume gentle nutrition while on this product, but that even caused stomach upset. I am not sure what to do next. When I res he’d put to the help team pop-up on the website, they said they don’t help with this kind of information, that I should email customer service. I will do that next."

— Laurel W. (2/5)

Seems to be working

"I take this with 3 other supplements from Dr. Ruscio. . no negative effects and I do feel it is helping."

— Michelle L. (5/5)

Biota-clear 1b

"I am taking this along with 1a and Remove. I am early in the process but appear to be having some improvement."

— James P. (5/5)

Wonderful supplement

"Works great to boost immune system during flu season"

— Renita W. (5/5)

Easy on the Stomach

"I have been taking this supplement for gut support. It is easy on the stomach and seems to be doing its job."

— Magdalena F. (5/5)

Great Product

"I am using Biota-Clear 1b as part of an anti microbial protocol that my naturopathic doctor put me on. I like the blend of these ingredients and trust the quality. So far so good."

— Victoria B. (5/5)

My use of Clair 1a and 1b

"The stomach pain and bloating has stopped!"

— Anita R. (5/5)

Useful !

"Early on in the program thus far, but I have already noticed a difference."

— Wesley R. (5/5)

Biota

"Does not work"

— Sophia P. (1/5)

Q&A

Will this help with ulcerative colitis?
This could be part of a gut healing protocol, yes! For treatment options: https://drruscio.com/colitis-treatment/

Frequently Asked Questions

Frequently Asked Questions

When Should I Start Taking Antimicrobials as Part of a Gut Healing Program?

Antimicrobials are Step 3 of my Great-in-8 gut healing protocol. Before taking herbal antimicrobials, it’s important to first set the foundation for gut health by getting adequate sleep, reducing stress, exercising, spending time in nature, improving diet and taking high-quality probiotic supplements. These foundational approaches set the stage for antimicrobial treatment and support long-term success once antimicrobial treatment is completed.

What’s the Suggested Duration of an Antimicrobial Treatment?

The Great-in-8 protocol recommends beginning with a 2-month course of treatment, rotating between Biota Clear 1a/1b and Biota Clear 2a/2b. An assessment at the end of the 2-month treatment will help you determine if additional treatments are needed.

Are Die-Off Reactions Possible?

Die-off reactions are an uncommon side effect that can occur when bad microbes die inside your body as a result of taking antimicrobials. Die-off may lead to:

  • Increased fatigue

  • Headaches

  • Digestive upset

  • Flu-like symptoms

Symptoms are usually temporary and are generally a sign that antimicrobial supplements are working. If symptoms last longer than a week, you may be intolerant of the herbal formula.

What Can I Do to Reduce Die-Off Reactions?

Reduce your dosage until you no longer experience reactions and then gradually increase to reach full dosage. If you continue to have symptoms, it’s best to switch to another herbal antimicrobial product.

Why Do You Sell Several Different Biota-Clear Products?

Research suggests that rotating antimicrobial treatments is 20% more effective than single treatments for remediating SIBO [10]. Rotating antimicrobials can also help to prevent antimicrobial resistance, which is when microorganisms adapt and become less susceptible antimicrobial agents. 

Frequently Bought Together

Biota-Clear 1a

Biota-Clear 1a

Botanical antimicrobial support for gut balance

Biota-Clear 2a

Biota-Clear 2a

The other second Biota-Clear step. Olive leaf, black walnut, berberine, & sweet wormwood.

Biota-Clear 2b

Biota-Clear 2b

The second Biota-Clear step. Caprylic acid, black walnut, oregano oil & pau d’arco.