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Biota-Clear 2a

Biota-Clear 2a

Biota-Clear 2a

The Biota Clear series provides powerful, botanical support for gut and immune function via multiple mechanisms:

  • Helps to restore healthy balance to the gut ecosystem
  • Exerts powerful anti-bacterial, anti-fungal, anti-parasitic, and anti-biofilm activity
  • Provides a milder alternative to prescription antibiotics and antifungals for stubborn gut dysbiosis
  • Produces anti-inflammatory benefits and may have antidepressant effects
  • May promote healthy motility 
  • May reduce pain
  • Long history of use by traditional cultures to treat digestive conditions. 
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  • Helps correct stubborn microbial imbalances in the gut 
  • Fights bad bugs 
  • May promote healthy motility and reduce inflammation 
  • Dr. Ruscio’s custom formulation
  • Based upon published research & Dr. Ruscio’s clinical experience

Suggested Use

  • For correcting microbial imbalances in the gut
    • Take 2 capsules twice daily together with Biota Clear 2b
    • Rotate with Biota Clear 1a + 2a after one month
  • For ongoing health maintenance, take 2 capsules daily
  • Can be taken with or without food

Product Facts

  • Ingredients include olive leaf (active ingredient oleuropein), black walnut, berberine, sweet wormwood /artemisinin.
  • Formulated from the highest quality ingredients.
  • Free from: wheat, gluten, soy, milk/casein, eggs, fish, shellfish, tree nuts and peanuts.
  • Contains no artificial colors, flavors, or preservatives.

You CAN Overcome Brain Fog & Depression by Healing Your Gut

Harman’s case is one that really pulls at your heart strings. At only 24 years old, she came in to my office debilitated by brain fog, to the point she had to take medical leave from her job. At our first visit she broke down with tears in her eyes in frustration and fear regarding her health. While we had to personalize her treatment to avoid reactions, ultimately she was free of all her symptoms in only 3-4 months. How? By healing her gut. This is a shining example of the gut-brain connection.

Why Dr. Ruscio, DC Recommends it

  • In some cases imbalances of the gut microbiota persist despite healthy inputs (better sleep, reduced stress, exercise, time in nature, diet and probiotics). This is where a gentle nudge with herbal antimicrobials can help recalibrate the gut ecosystem to a healthier equilibrium.
  • The best research data we have for antimicrobials is for the non-herbal antibiotic rifaximin (aka Xifaxan) which has clearly been shown to reduce unwanted bacteria in SIBO [1, 2] and is FDA approved for treating IBS [3, 4].
  • There are fewer studies for herbal antimicrobials, however they have also been shown to be effective for SIBO and IBS [5, 6].
  • However, return of symptoms after treatment is somewhat common after rifaximin. Why? I believe this tends to happen when long-term supports are not in place. So, when the crutch of the antibiotic is gone, the gut ecosystem slowly returns to its imbalanced state.
  • Herbal antimicrobials have more beneficial side benefits when compared with rifaximin. They are anti-inflammatory and perhaps even antidepressant [7, 8]. Many plant-based antimicrobials act against bacteria, fungi, and protozoa while prescription antibiotics mostly work against bacteria [9].
  • Our Biota-Clear line of antimicrobials has been shaped by my clinical experience and the published literature.
  • An overwhelming amount of anecdotal data from patients and from readers suggests this approach works well, even for those who have somewhat chronic and severe conditions.

What the Research Shows

  • Herbal preparations may be as effective as prescription antibiotics at treating SIBO and IBS [6].
  • Rotating antimicrobial treatments may be 20% more effective than a single treatment for remediating SIBO [10].


  • A randomized clinical trial (gold standard research) found that 8 weeks of berberine reduced the frequency of diarrhea, abdominal pain, and urgency, and improved quality of life in IBS-D patients [5].
  • Animal study data indicates that berberine sets in train changes that may lead to reduced intestinal lining inflammation. Berberine also lowered gut sensitivity [11].
  • A systematic review / meta-analysis (SR/MA) of 13 randomized controlled trials (RCTs) found that adding berberine to standard therapy for H. pylori improved the eradication rate, raised the peptic ulcer healing rate, and reduced clinical symptoms and side effects (compared to standard therapy without berberine) [12].
  • A 2019 SR/MA of 5 RCTs found that berberine likely decreased serum CRP (c-reactive protein) levels, thus relieving chronic inflammation [13].
  • Berberine reduced blood glucose, HbA1c, triglycerides, total cholesterol, and LDL-C compared with placebo [14].
  • A 2015 rat study found berberine improved IBS-D symptoms, possibly via opioid receptors [15].

Artemisinin (Artemisia annua, Sweet Wormwood)

  • Artemisinin has been found in animal, in vitro, and some human clinical studies, to exhibit antimicrobial, anti-inflammatory, and gut microbiome modulating effects. For example:
    • Artemisinin helped in the treatment of malaria, resolving symptoms and  inhibiting malarial parasites (though with limited efficacy where parasites had developed resistance) [16, 17, 18, 19].
    • A 2020 study found that mice treated with dihydroartemisinin (DHA), a semisynthetic form of artemisinin, had, higher bacterial diversity (including increased Firmicutes and Saccharibacteria and decreased Deferribacteres and Actinobacteria relative to controls) [20].
    • In vitro studies show that artemisinin demonstrates anti-fungal and anti-yeast activity [21, 22].

Black Walnut

  • An in vitro study found that black walnut tannins demonstrated antibacterial effects against Listeria, S. aureus, E. coli, Brochothrix thermosphacta, Pseudomonas fragi, Salmonella, and Lactobacillus plantarum [23].

Olive Leaf Extract

  • A study showed that oleuropein (the active ingredient of olive leaf extract) helped calm inflammatory damage in colonic samples taken from ulcerative colitis patients [24].
  • A proprietary mix of oleuropein (the active and hydroxytyrosol reduce blood pressure and lipid in males with slightly raised blood pressure [25].
  • A one off dose of oleuropein and hydroxytyrosol also reduced inflammatory cytokine (IL-8) production over 24 hours [26].
  • Randomized clinical trials also show olive leaf extract can lower HbA1c levels and fasting insulin and may have benefits for those at risk of developing metabolic syndrome [27, 28].
Elemental Heal has definitely helped in the recovery of my gut, but even more importantly with my energy levels.

I've worked with some of the best minds in gut health and of all I've tried Dr. Ruscio's antimicrobials were one of the most impactful interventions for my gut.

—Robb Wolf

New York Times best selling author

How to Use it

As part of Dr. Rusico’s protocol

Refer to the full Great-in-8 protocol that Dr. Ruscio uses in his clinic and outlines in his book, Healthy Gut, Healthy You.

In a low dose for ongoing maintenance

After going through the full protocol, a lower dose can be used for a few additional months to help encourage a healthy rebalancing in the gut.

For periodic relapses

Life happens as do relapses. If so, a re-visitation of the full protocol can help get you back on track. Make sure to only do this after first revisiting diet and probiotics.

What's Inside?

90 Caps
  • 90 Caps

Frequently Asked Questions

When Should I Start Taking Antimicrobials as Part of a Gut Healing Program?

Antimicrobials are Step 3 of my Great-in-8 gut healing protocol. Before taking herbal antimicrobials, it’s important to first set the foundation for gut health by getting adequate sleep, reducing stress, exercising, spending time in nature, improving diet and taking high-quality probiotic supplements. These foundational approaches set the stage for antimicrobial treatment and support long-term success once antimicrobial treatment is completed.

What’s the Suggested Duration of an Antimicrobial Treatment?

The Great-in-8 protocol recommends beginning with a 2-month course of treatment, rotating between Biota Clear 1a/1b and Biota Clear 2a/2b. An assessment at the end of the 2-month treatment will help you determine if additional treatments are needed.

Are Die-Off Reactions Possible?

Die-off reactions are an uncommon side effect that can occur when bad microbes die inside your body as a result of taking antimicrobials. Die-off may lead to:

  • Increased fatigue
  • Headaches
  • Digestive upset
  • Flu-like symptoms

Symptoms are usually temporary and are generally a sign that antimicrobial supplements are working. If symptoms last longer than a week, you may be intolerant of the herbal formula.

What Can I Do to Reduce Die-Off Reactions?

Reduce your dosage until you no longer experience reactions and then gradually increase to reach full dosage. If you continue to have symptoms, it’s best to switch to another herbal antimicrobial product.

Why Do You Sell Several Different Biota-Clear Products?

Research suggests that rotating antimicrobial treatments is 20% more effective than single treatments for remediating SIBO [10]. Rotating antimicrobials can also help to prevent antimicrobial resistance, which is when microorganisms adapt and become less susceptible antimicrobial agents.