Biota-Clear 2b

Biota-Clear 2b

Biota-Clear 2b

Pairs with Biota-Clear 2a Step 3 of the Great-in-8 Protocol
1 6

Biota-Clear 2b

Biota-Clear 2b

Pairs with Biota-Clear 2a Step 3 of the Great-in-8 Protocol

The Biota Clear series provides powerful, botanical support for gut and immune function via multiple mechanisms:

  • Helps to restore healthy balance to the gut ecosystem
  • Exerts powerful anti-bacterial, anti-fungal, anti-parasitic, and anti-biofilm activity
  • Provides a milder alternative to prescription antibiotics and antifungals for stubborn gut dysbiosis
  • Produces anti-inflammatory benefits and may have antidepressant effects
  • May promote healthy motility
  • May reduce pain
  • Long history of use by traditional cultures to treat digestive conditions. 
Wheat-Free

Wheat-Free

Gluten-Free

Gluten-Free

Soy-Free

Soy-Free

Casein-Free

Casein-Free

$26.99 $29.99
Pause, Skip, or Cancel at Any time
Makes Consistency Easy
Exclusive Gifts & Training
$29.99
  • Free domestic shipping on all orders over $109.
View full details

How to Use Biota-Clear 2b

On Its Own

For general microbial support, outside a structured protocol.

Dose
2 capsules, twice daily

As Part of the Biota-Clear Protocol

Used with Biota-Clear 2a as the antimicrobial phase, often rotated with the 1a/1b formulas.
Dose
3 capsules twice daily, alongside 2a
Pairs with: Biota-Clear 2a

As Part of the Biofilm Protocol

Weeks 1–4
Biota-Clear 1a + 1b
Weeks 5–8
3 capsules twice daily, alongside Biota-Clear 2a (3 caps 2×) and Biota-Dissolve (3 caps 2×, away from meals)
Full protocol and dosing chart

*Typically used alongside Biota-Clear 2a and rotated with other Biota-Clear formulas over time.

Why does the label say “Step 3”?

This label reflects Biota-Clear 2b's place in the Great-in-8 protocol from Dr. Ruscio's book, Healthy Gut, Healthy You. Steps 1 and 2 are foundational work (diet and lifestyle, then probiotics) that typically come before antimicrobials. Biota-Clear 1a and 1b are the antimicrobial step, used together.

Explore the protocol
Great-in-8 · first three steps
Step 1: Diet & lifestyle Foundational work
Step 2: Probiotics Support before antimicrobials
Step 3: Antimicrobials Biota-Clear 2a + 2b, used together

Why Choose
Biota-Clear 2b?

1
Holistic Botanical Formula
Combines olive leaf, black walnut, berberine, and sweet wormwood for a multi-targeted approach.
2
Clinically-Inspired Effectiveness
Crafted from Dr. Ruscio’s extensive clinical experience and supported by relevant research.
3
Commitment to Purity
Guaranteed free from common allergens and devoid of artificial substances, upholding the highest standards of safety and quality.

Breaking Through SIBO Biofilms

  • Biofilms may allow certain microbes to persist and limit treatment progress. In this video, I explain how our clinical team uses the Biota-Clear formulas in a rotating protocol designed to help disrupt biofilms and support healthier microbial balance.

  • Want to see how the full protocol works?

  • Explore the Biota-Clear Protocol →

What the Research Shows

  • Herbal preparations may be as effective as prescription antibiotics at treating SIBO and IBS [6].
  • Rotating antimicrobial treatments may be 20% more effective than a single treatment for remediating SIBO [10].
  • Oregano, Thymol and Carvacrol
  • Six weeks of 600 mg of daily oregano oil (O. vulgare) reduced or eliminated parasites in 16 individuals. In seven of the 11 patients infected with Blastocystis hominis, GI symptoms improved [11].
  • Thymol and carvacrol (active ingredients in oregano oil)  improved symptoms in IBS patients relative to placebo [12].
  • Oregano extracts demonstrated antimicrobial, antiviral, antioxidant, insecticidal, anticancer, hepatoprotective, genotoxic, antidiabetic, cholinesterase inhibitory, anti-inflammatory, and analgesic actions [9].
  • Animal studies also suggest that oregano extracts have a potential mood-enhancing effect [8].
  • Thymol: 
  • • Reduces gut inflammation
  • • Stimulates digestive enzymes
  • • Attenuates ulcers
  • • Works as an ileal antispasmodic and anti-spasmolytic
  • • Inhibits gastric mucosal injury
  • • Influences gastric maturation and function in animal studies [13].
  • Caprylic Acid
  • Caprylic acid can reduce the bad bacteria animals and chickens carry in their guts according to a number of studies [14, 15, 16].
  • Neurodegenerative disease models suggest that caprylic acid may confer neuroprotective and mitochondria-protective effects and may strengthen antitumor actions in the case of brain cancer [17].
  • Black Walnut (Juglans nigra)
  • An in vitro study found that black walnut tannins demonstrated antibacterial effects against Listeria, S. aureus, E. coli, Brochothrix thermosphacta, Pseudomonas fragi, Salmonella, and Lactobacillus plantarum [18].
  • Pau D’Arco (Tabebuia impetiginosa)
  • Test tube and animal studies have shown pau d’arco extracts to have significant antioxidant and anti-inflammatory effects [19, 20].
  • Lapachol, an active ingredient in pau d’arco extracts, was also found (in vitro) to inhibit bad bacteria (Clostridia and E. coli), while not affecting good bugs such as Bifidobacteria, Lactobacillus acidophilus, and Lactobacillus casei [21].

Why Dr. Ruscio Recommends It

Why Dr. Ruscio Recommends It

Herbal Antimicrobials: A Gentle Recalibration

In some cases imbalances of the gut microbiota persist despite healthy inputs (better sleep, reduced stress, exercise, time in nature, diet and probiotics). This is where a gentle nudge with herbal antimicrobials can help recalibrate the gut ecosystem to a healthier equilibrium.  

Rifaximin: The Gold Standard

The best research data we have for antimicrobials is for the non-herbal antibiotic rifaximin (aka Xifaxan) which has clearly been shown to reduce unwanted bacteria in SIBO [1, 2] and is FDA approved for treating IBS [3, 4].

There are fewer studies for herbal antimicrobials, however they have also been shown to be effective for SIBO and IBS [5, 6].

However, return of symptoms after treatment is somewhat common after rifaximin. Why? I believe this tends to happen when long-term supports are not in place. So, when the crutch of the antibiotic is gone, the gut ecosystem slowly returns to its imbalanced state. 

Sustainable Gut Health: Beyond Antibiotics

Herbal antimicrobials have more beneficial side benefits when compared with rifaximin. They are anti-inflammatory and perhaps even antidepressant [7, 8]. Many plant-based antimicrobials act against bacteria, fungi, and protozoa while prescription antibiotics mostly work against bacteria [9].

Biota-Clear: Clinical Wisdom in Action

Our Biota-Clear line of antimicrobials has been shaped by my clinical experience and the published literature.  

An overwhelming amount of anecdotal data from patients and from readers suggests this approach works well, even for those who have somewhat chronic and severe conditions.

Overall rating: 4.321429 / 5 from 28 reviews.

AI Generated Review Summary

Summary topics

Review topics: [improvement, effects, difference, gastritis, gut, gut, biota-dissolve line-up of products].

Review highlights

Reviews

Wide Range Herbal Antibiotic

"I believe it is working. I took 2 months of antimicrobials. Protocol based off of Healthy Gut, Healthy you book. Remember for the exact dosage check out the book. The Key for the best Protocol is finding out which kind of SIBO you have."

— Prince W. (5/5)

Just started

"I have just started with the herbal treatment, day 3 and excited to see the resultat."

— Noshoor K. (3/5)

Works Great!

"I’ve finished with two months of the Biota Clear protocol and other Great-in-8 supplements and am almost symptom free."

— Jeanni D. (5/5)

I notice improvement since taking

"I notice improvement since taking 2b after 1a and 1 b."

— Doug N. (5/5)

Use it for maintenance

"I take two Biota clear on an empty stomach morning and night to clear biofilm and plaque."

— anne e. (4/5)

A good support!

"This has proven to be helpful in the Step 2 Removal protocol while healing from SIBO."

— Phileena N. (5/5)

Really helped

"I’ve been taking this with 2a for a month and have significant improvement in my gut."

— Jane U. (5/5)

Great product

"My gut has been so much better since starting this a month ago!"

— Lacy D. (5/5)

Healthier Gut

"I've noticed a clear difference in my energy level and reduction of GI symptoms since I started taking this."

— Gabriella C. (5/5)

Vital to gut health

"I have been struggling with gut issues for 18 years. I know huge part of this is overgrowth of bacteria and fungus. There is no easier fast way to cleanse the unwanted organisms in our gut, but this product along with the others is a step towards health."

— Karis M. (4/5)

Q&A

Frequently Asked Questions

Frequently Asked Questions

When Should I Start Taking Antimicrobials as Part of a Gut Healing Program?

Antimicrobials are Step 3 of my Great-in-8 gut healing protocol. Before taking herbal antimicrobials, it’s important to first set the foundation for gut health by getting adequate sleep, reducing stress, exercising, spending time in nature, improving diet and taking high-quality probiotic supplements. These foundational approaches set the stage for antimicrobial treatment and support long-term success once antimicrobial treatment is completed.

What’s the Suggested Duration of an Antimicrobial Treatment?

The Great-in-8 protocol recommends beginning with a 2-month course of treatment, rotating between Biota Clear 1a/1b and Biota Clear 2a/2b. An assessment at the end of the 2-month treatment will help you determine if additional treatments are needed.

Are Die-Off Reactions Possible?

Die-off reactions are an uncommon side effect that can occur when bad microbes die inside your body as a result of taking antimicrobials. Die-off may lead to:

  • Increased fatigue
  • Headaches
  • Digestive upset
  • Flu-like symptoms

Symptoms are usually temporary and are generally a sign that antimicrobial supplements are working. If symptoms last longer than a week, you may be intolerant of the herbal formula. 

What Can I Do to Reduce Die-Off Reactions?

Reduce your dosage until you no longer experience reactions and then gradually increase to reach full dosage. If you continue to have symptoms, it’s best to switch to another herbal antimicrobial product.

Why Do You Sell Several Different Biota-Clear Products?

Research suggests that rotating antimicrobial treatments is 20% more effective than single treatments for remediating SIBO [10]. Rotating antimicrobials can also help to prevent antimicrobial resistance, which is when microorganisms adapt and become less susceptible antimicrobial agents.

Frequently Bought Together

Biota-Clear 1a

Biota-Clear 1a

Botanical antimicrobial support for gut balance

Biota-Clear 1b

Biota-Clear 1b

Powerful herbal antimicrobials support gut and immune function (pair with 1a).

Biota-Clear 2a

Biota-Clear 2a

The other second Biota-Clear step. Olive leaf, black walnut, berberine, & sweet wormwood.