On Its Own
For general microbial support, outside a structured protocol.
Dose
3 capsules, twice daily
Biota-Clear 1a
Biota-Clear 1a
Pairs with Biota-Clear 1b
Step 3 of the Great-in-8 Protocol
Biota-Clear 1a is a botanical supplement formulated to support microbial balance and gut ecosystem resilience using concentrated plant-based compounds.
Features a potent oil of oregano extract standardized for carvacrol and thymol, two well-studied botanical constituents
Designed for people seeking targeted botanical support beyond foundational diet and probiotic strategies
Can be used on its own or as part of Dr. Ruscio’s Mold & Fungus Protocol, where botanical compounds are layered intentionally within a broader approach
Non-GMO
Gluten-Free
Allergen-Free
No Artificial Ingredients
Regular price
$22.95
Sale price
$22.95
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How to Use Biota-Clear 1a
As Part of the Biota-Clear Protocol
Used with Biota-Clear 1b as the antimicrobial phase, often rotated with the 2a/2b formulas.
Dose
3 capsules twice daily, alongside 1b
As Part of the Biofilm Protocol
Weeks 1–4
4 capsules twice daily, alongside Biota-Clear 1b (2 caps 2×) and Biota-Dissolve (3 caps 2×, away from meals)
Weeks 5–8
Rotates to Biota-Clear 2a + 2b
*Typically used alongside Biota-Clear 1b and rotated with other Biota-Clear formulas over time.
Why does the label say “Step 3”?
This label reflects Biota-Clear 1a's place in the Great-in-8 protocol from Dr. Ruscio's book, Healthy Gut, Healthy You. Steps 1 and 2 are foundational work (diet and lifestyle, then probiotics) that typically come before antimicrobials. Biota-Clear 1a and 1b are the antimicrobial step, used together.
Great-in-8 · first three steps
Step 1: Diet & lifestyle
Foundational work
Step 2: Probiotics
Support before antimicrobials
Step 3: Antimicrobials
Biota-Clear 1a + 1b, used together
What people say about Biota-Clear 1a
Why Choose
Biota-Clear 1a?
1
Targeted Botanical Formula
Uses standardized oregano oil compounds selected for protocol use.
2
Part of a Rotational System
Designed to be rotated with other Biota-Clear formulas to avoid stagnation.
3
Clinician-Developed
Formulated based on published research and extensive clinical experience.
Breaking Through SIBO Biofilms
Biofilms may allow certain microbes to persist and limit treatment progress. In this video, I explain how our clinical team uses the Biota-Clear formulas in a rotating protocol designed to help disrupt biofilms and support healthier microbial balance.
Want to see how the full protocol works?
What the Research Shows
Who It´s For
Ingredients
- Oregano oil
- Olive oil
- Bovine Gelatin
- Vegetable Glycerin
- Purified Water
Overall rating: 4.7108436 / 5 from 83 reviews.
AI Generated Review Summary
Biota-Clear 1a offers a natural solution for gut dysbiosis, featuring powerful botanical support with oregano oil. Users can expect reduced inflammation, improved motility, and relief from digestive discomfort. The product is praised for its high quality and consistent results, providing an effective alternative to harsh prescriptions.
Summary topics
- Product Quality (12%): It was highlighted by customers that the product has high quality and is consistent in its results.
- Botanical Support (10%): Customers expressed appreciation for the great quality of the supplements at Ruscio Institute, praising their affordability and effectiveness.
Review topics: ["improvement","quality","feeling","issues","bottle","symptoms","oil","difference","stomach","outcome","supplement","change","antibiotics","foods","pills","gut","health","sibo"].
Review highlights
- "This supplement was well priced and great quality!" —
- "I can sense the high quality nature of these products." —
- "Not sure if it is working for me, but it seems to be good quality it has a rich smell" —
Reviews
Substantial Change
"I have felt horrible since the SIBO test and antibiotics. I tried probiotics for 3 months which provided some improvement, but this is the step I needed for my SIBO and motility issue. I'm almost through 1a/b and have the 2a/b series on hand. I have an appetite back, although I still stick with liquid meals in the morning. My BMs are regular without being back to full normal so I am loving the progress on this product."
NICE
"So far so good-but time will tell if truly working"
Disappointed
"The Biota Clear system is confusing—the website was confusing to find the information of what to use and when. When I finally found the information, it wasn’t clear—there is way too much going on on the webpage and you have to scroll down to get a somewhat clear idea of the steps. I appreciated the study and the YouTube video about the study; those were helpful. I finally determined that this system is what I needed based on my symptoms. But once I got it, I realized the label says “Step 3”. What are steps 1 & 2? If there are steps 1&2, why isn’t that stated anywhere on the page with a link to steps 1&2? I decided to use it anyway based on the product and symptoms description— starting with the Biota Dissolve, the 1a & 1b as directed. After 3 days everything got worse and unbearable. I had to stop taking the meds, as it was affecting everything from sleep, to being at work, my daily activities, etc. I couldn’t function. I got terrible watery stool immediately after eating, and intense inflammation. I’m disappointed as I had high hopes, and it’s not a cheap product line. But at least I know now. I even tried the Elemental Heal I have to see if maybe I just needed to consume gentle nutrition while on this product, but that even caused stomach upset. I am not sure what to do next. When I res he’d put to the help team pop-up on the website, they said they don’t help with this kind of information, that I should email customer service. I will do that next."
This stuff works for Dematiaceous Fungi
"I got some of this awhile back bc I have SIFO from the fungi Dematiaceous, the type I have uses both beta d glucan and chitin, the product has both glucanase, chitrinese both breakdown beta glucans and chitin and it also has EDTA. The product really helped a ton."
Small capsules
"I take 8 of these a day and I have been feeling better."
Oregano Clear
"I have been using the Biota-Clear oregano oil supplement for a couple of weeks. I suggest starting gradually as I expericned some slight abdominal discomfort the first couple of days but since have been taking it with food everyday and am noticing less bloating which is great."
Biota clear 1a
"This supplement has been great to help my immune system. I have been exposed to Covid while taking this and did not get sick."
This Worked!
"Less bloat and less pain! And the oil did not make me burb like similar products I have used in the past"
Excellent Product
"This product helped rid off viral infection that affected digestion, dental and oral issues."
Quality Product
"I like the effectiveness of the Biota Clear 1a supplement and am using it in an anti microbial protocol. I appreciate the quality of the supplements at Ruscio Institute."
Q&A
- Will this help with ulcerative colitis?
- This could be part of a gut healing protocol, yes! For treatment options: https://drruscio.com/colitis-treatment/
- Dear Dr. Ruscio, In your book it says we need two bottle of the Biota-Celar 1b and if we have left over, take it into month two...but if i take 3 pills morning and 3 pills at night, i will be out of pills in 20 days if i have two bottles...do I need three bottles or is two the right number of bottles and 20 days on Biota Clear 1a? Thank you
- The dose for 1b is 2 pills twice a day, so 2 bottles should give you enough for the month.
- Is this product safe to take while breastfeeding—i.e., not while pregnant—a 3.5 year old? Are there any “kill phase” products that can be safely taken while breastfeeding?
- Our antimicrobials should be avoided while breastfeeding. Dr. Ruscio discusses which products should be avoided while breastfeeding during his protocol here: https://drruscio.com/great-in-8-faq-step1/
- Is this safe to take while breastfeeding?
- We do not recommend using this product while pregnant
Frequently Asked Questions
Frequently Asked Questions
What is Biota-Clear 1a typically used for?
Biota-Clear 1a is designed to support gut microbial balance, rather than target a specific diagnosis.
It’s used by individuals looking for botanical support in a variety of contexts, including general gut microbial imbalances. It is also included in Dr. Ruscio’s Mold & Fungus Protocol, where it’s used as part of a broader, structured approach. Individual use varies based on goals and needs.
Biota-Clear 1a can be used:
On its own for general microbial support
As part of a targeted protocol
In rotation with other formulas to support broader balance
Should I start with antimicrobials?
Antimicrobials are typically introduced after foundational gut health steps like diet, probiotics, sleep, and stress support.
How long is a typical protocol?
Protocols often last 1–2 months, with rotation between formulas. Individual needs vary.
Why rotate Biota-Clear products?
Rotation helps prevent stagnation and supports broader microbial balance. [3].
Are die-off reactions possible?
Some individuals may notice temporary symptoms when changing gut microbial activity. Reducing dose and gradually increasing may help.
Is this product specific to mold or fungal protocols?
Biota-Clear 1a is used within Dr. Ruscio’s Oral Mold & Fungus Antimicrobials & Antibiofilm Agents protocol as part of a broader approach to supporting microbial balance. It is not intended to diagnose or treat mold-related illness and is used in conjunction with other supportive strategies.
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